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Rheumatoid arthritis (RA) is the most common chronic autoimmune arthritis worldwide, leading to disability and substantial economic costs. It is a chronic and systemic inflammatory disorder that may affect many tissues and organs, but principallyattacks synovial joints.
ichroma™ RF-IgM Test is based on fluorescence immunoassay technology. ichroma™ RF-IgM uses a sandwich immunodetection method, such that by mixing detector buffer with blood specimen in test vial, the fluorescence-labeled detector anti-RF-IgM antibody in buffer binds to RF-IgM antigen in blood specimen. The sample mixture is loaded and migrates on the matrix of test cartridge; the complexes of detector antibody and RF-IgM are captured to anti-RF-IgM sandwich pair antibody that has been immobilized on test matrix.