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In healthy people, plasma Procalcitonin (PCT) concentrations are found to be below 0.1 ng/mL. PCT levels rise rapidly (within 6 – 12 hours) after a bacterial infectious insult with systemic consequences. Early after situations like multiple traumas, majorsurgery, severe burns, or in neonates, PCT levels can be elevated independently of an infectious process, but the return to baselineis usually rapid. Viral infections, bacterial colonization, localized infections, allergic disorders, autoimmune diseases, andtransplant rejection do not usually induce a significant PCT response (values < 0.5 ng/mL). By evaluating PCT concentrations, the physician may use the findings to aid in the risk assessment forprogression to severe sepsis and septic shock.
ichroma™ PCT Test is based on fluorescence immunoassay technology. ichroma™ PCT uses a sandwich immunodetection method, such that by mixing detector buffer with blood specimen in test vial, the fluorescence-labeled detector anti-PCT antibody in buffer binds to PCT antigen in blood specimen. The sample mixture is loaded and migrates on the matrix of test cartridge; the complexes of detector antibody and PCT are captured to anti-PCT sandwich pair antibody that has been immobilized on test matrix.