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Albumin is normally found in the blood and filtered by the kidneys. When the kidneys are working properly, albumin is not present in the urine. When the kidneys are damaged, small amounts of albumin leak into the urine. This condition is called microalbuminuria. Microalbuminuria is most frequently caused by kidney damage fromdiabetes. However, many other conditions can lead to kidney damage, such as high blood pressure, heart failure, cirrhosis, orsystemic lupus erythmatosus (SLE). When the kidneys spill protein, it can mean serious kidney damage is present. This can leadto chronic kidney disease.
ichroma™ Microalbumin Test is based on fluorescence immunoassay technology. ichroma™ Microalbumin uses a sandwich immunodetection method, such that by mixing detector buffer with blood specimen in test vial, the fluorescence-labeled detector anti-Microalbumin antibody in buffer binds to Microalbumin antigen in blood specimen. The sample mixture is loaded and migrates on the matrix of test cartridge; the complexes of detector antibody and Microalbumin are captured to anti-Microalbumin sandwich pair antibody that has been immobilized on test matrix.