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The C-Reactive Protein (CRP) is synthesized by the liver in response to interleukin-6 and well known as one of the classical acute-phase reactants and as a marker of inflammation. CRP is the first acute-phase protein to be described and is an exquisitely sensitive systemic marker of inflammation and tissue damage. The serum CRP level may rise from a normal level of <5 mg/L to 500 mg/L during the body’s general, non-specific response to infectious and other acute inflammatory events.
ichroma™ CRP Test is based on fluorescence immunoassay technology. ichroma™ CRP uses a sandwich immunodetection method, such that by mixing detector buffer with blood specimen in test vial, the fluorescence-labeled detector anti-CRP antibody in buffer binds to CRP antigen in blood specimen. The sample mixture is loaded and migrates on the matrix of test cartridge; the complexes of detector antibody and CRP are captured to anti-CRP sandwich pair antibody that has been immobilized on test matrix.