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CarcinoEmbrlyonic Antigen (CEA) is an oncofetal glycoprotein, which is found at high levels in the fetal colon and at lower levels in the normal adult colonic epithelium. CEA occurs at abnormally high levels in several benign disorders and in some malignant tumors, including those of the stomach, small intestine, colon, rectum, pancreas, liver, breast, ovary, cervix, and lung. Levels of CEA are significantly lower in colon tissue of adults, but can become elevatedwhen inflammation or tumors’ arise in any endodermal tissue, including in the gastrointestinal tract, respiratory tract, pancreas and breast.
ichroma™ CEA Test is based on fluorescence immunoassay technology. ichroma™ CEA uses a sandwich immunodetection method, such that by mixing detector buffer with blood specimen in test vial, the fluorescence-labeled detector anti-CEA antibody in buffer binds to CEA antigen in blood specimen. The sample mixture is loaded and migrates on the matrix of test cartridge; the complexes of detector antibody and CEA are captured to anti-CEA sandwich pair antibody that has been immobilized on test matrix.