Skip to main content Skip to navigation

Flow Forward

Sail towards the future of clinical flow cytometry from patient screening to patient monitoring

Integrated Clinical Solutions
Down Arrow
What does it mean to flow?

Ease. Progress. Reliability.


When your flow cytometry laboratory flows, everyone and everything plays their part.


Your teams feel supported, your systems perform as designed and your results inspire clinical confidence.


Integrated solutions that link every step of the testing pathway can help you sail towards the future of clinical flow cytometry, from patient screening to patient monitoring.

Video Player is loading.
Current Time 0:00
Duration 0:00
Loaded: 0%
Stream Type LIVE
Remaining Time 0:00
 
1x
    • Chapters
    • descriptions off, selected
    • subtitles off, selected

      What if you could improve patient care with greater results accuracy?

      You and your flow cytometry laboratory are vital to enabling rapid, reliable clinical decision making.


      Clinicians and patients alike trust you to provide consistent, timely and quality results, and the quality of those results is dependent on the standardisation of your laboratory workflow.1


      However, standardisation isn’t always simple. Compliance challenges are compounded by the increasingly complex regulations, not to mention budget constraints and laboratory errors.


      How can you ensure standardised laboratory practices to ensure positive patient outcomes?

       
      performance1

      What if you could increase lab efficiency with integrated solutions that support you and your team?

      Workflow inconsistency, lack of standardisation, extended manual processes, staff shortages - your flow cytometry workflow undergoes an often overwhelming number of challenges that can influence your overall efficiency.


      It may feel that to take one step forward, you are taking two steps back.

       

      How can you implement efficient, standardised flow cytometry processes that support you and your team’s performance goals?

       
      performance1

      Solutions that flow, from patient screening to patient monitoring

      While you’re committed to positively impacting patients’ lives, we’re committed to advancing your work through automation, standardisation and performance.


      We’ve expanded our clinical flow cytometry family with integrated solutions to better support clinicians, patients and lab teams in oncohaematology, immunology, transplantation and transfusion.


      Discover complete CE-IVD solutions for blood cancer diagnostics and immune assessment tests and learn how to address the needs of clinicians to better understand the immune system, immune response and minimal residual disease (MRD).


       

      Integrated clinical solutions that flow, from sample to answer

       

      Through the automation, standardisation and performance of our complete clinical laboratory solutions, you can achieve the efficiency and productivity you need to keep moving forward.

      Standardisation and Automation

      How can standardisation help you?

      Standardisation is the consolidation of your laboratory systems and processes so that each task is performed in a way that benefits the whole workflow.

       

      Standardisation and improvements in laboratory technologies can play key roles1 in:

       

      • Enhancing results accuracy
      • Helping prevent errors
      • Increasing the quality of laboratory data

       


      How can automation help you?

      Automation helps to ensure that surges in patient specimen volumes do not impact quality, turnaround time and subsequently, the ability for clinicians to manage patient care effectively and safely.2-4


      In particular, laboratory automation has been shown to save time by improving efficiency, reducing hands-on time and allowing you to reallocate staff time to more value-adding tasks.2

       

       

      How does BD support?

      By delivering timely and accurate results that inform clinical decisions, the integrated BD solution supports patient safety and positive health outcomes.

       

      The BD FACSDuet™ and the BD FACSDuet™ Premium Sample Preparation Systems paired with the BD FACSLyric™ Flow Cytometer deliver process standardisation by minimising error-prone steps while increasing workflow consistency and laboratory efficiency.


      The BD FACSLyric™ combines simplicity, speed and automation to ease workload and improve productivity. This next-generation system enables flow cytometry workflow standardisation and collaboration through automation and unique assay portability capabilities.

       

      Powered by the BD Infinicyt™ Software, certain applications within the integrated BD workflow provide automation in data analysis and reporting with EuroFlow™ Reference Databases, giving you stronger resources that prioritise reproducibility through standardisation.


      The laboratory staff at the Nancy University Hospital in France decided to reorganise their flow cytometry practice with a full clinical solution. Now, data are directly transferred from the flow cytometers to their laboratory information system (LIS). 

       

      Learn more about the positive impacts BD integrated solution have had on efficiency and productivity by watching their story below.

      Video Player is loading.
      Current Time 0:00
      Duration 0:00
      Loaded: 0%
      Stream Type LIVE
      Remaining Time 0:00
       
      1x
        • Chapters
        • descriptions off, selected
        • subtitles off, selected

          Compliance - CE IVD

          CE-IVD portfolio

          In vitro diagnostic solutions within the BD Biosciences portfolio include flow cytometric immunophenotyping reagents for:

           

          • Diagnosing, classifying and monitoring haematological disorders
          • Monitoring human immunodeficiency virus (HIV)–infected individuals
          • Characterising and monitoring immune deficiencies and autoimmune diseases
          • Screening patients for suspicion of primary immunodeficiency
          • Cell enumeration of residual leucocytes in blood products for transfusion
          • Cell enumeration of CD34+ stem cells for haematopoietic stem cell transplants


          The European In Vitro Diagnostic Medical Device Regulation (IVDR) (EU) 2017/746 came into effect on 26 May 2017 and replaces the European In Vitro Diagnostic Medical Device Directive (IVDD) 98/79/EC. A global cross-functional team at BD Biosciences has been working to implement the new regulation in a seamless and compliant manner.


          EU IVDR Amending Regulations (EU) 2022/112 and (EU) 2023/607 expands the scope of the grace period to certain devices and the abolishment of the sell-off provisions of IVDR. Consequently, devices placed on the market before the end of the transition period can be made further available on the market without a time restriction.


          By your side through IVDR

          We are committed to providing IVDR compliant solutions to continue delivering safe and effective IVD medical devices to serve you and your patients. We received our first IVDR product certification back in December 2020 and the majority of BD’s previous IVDD compliant devices are now IVDR compliant. We are continuing our efforts to achieve this for current and new products in our clinical portfolio.


          Interested in solutions planned for IVDR compliance?

          Learn More
          performance1

          Data Analysis and Integration

          How can you simplify complex data analysis?

          You may feel that the more parameters you have when analysing flow cytometry data, the more challenges arise. With more analytic parameters

          comes more opportunity for user variability, which may be costing your laboratory valuable time and resources.

           


          How can automated analysis and reporting features help you?

          Implementing automation solutions can help you increase consistency and reproducibility while decreasing inter-operator variability.


          Automated analysis and reporting software features can:

           

          • Support standardisation and reproducibility
          • Help reduce inter-operator variability with less manual steps in analysis
          • Boost workflow efficiency with automated reporting, integrated bidirectional LIS connection and less error-prone steps

           

           

          How does BD support?

          BD Biosciences offers a unique set of clinical software and informatic tools that drives laboratory workflow efficiency, even through complex multiparametric data analysis, and inspires confidence in reported results.


          The BD FACSuite™ Clinical Application, the software behind the CE-IVD assays on the BD FACSLyric™ Flow Cytometry System, enables automated gating and analysis for a standardised, efficient and less error-prone workflow.


          The BD FACSuite™ Application offers streamlined workflow features to support setting up user-defined assays with unique and simple electronic assay portability that enables sharing of user-defined protocols within and between institutions.


          The BD Infinicyt™ Software was designed for multiparametric analysis of complex data, providing CE-IVD manual and automated data analysis and reporting when working with the intended uses of the appropriate BD CE-IVD panels for a comprehensive evaluation of pathological and rare cells to achieve the appropriate sensitivity.


          The BD FACS™ Workflow Manager is the BD Middleware solution, allowing bidirectional communication of test and patient data between the BD Clinical Solution Instrumentation, including the BD FACSLyric™ Flow Cytometry System and the BD FACSDuet™ System, standalone workstation and hospital and/or laboratory information system (HIS/LIS). By minimising manual tasks through features such as data storage, query and reporting on full testing history with original data files, it can help you reduce errors in results reporting.

          Flexibility

          How do you retain flexibility while prioritising standardisation?

          Standardisation and flexibility are not mutually exclusive. There are solutions that can keep you and your teams agile while still adhering to standardised protocols in the laboratory.


          With the help of automated solutions and software across the clinical flow cytometry workflow, you can enjoy the freedom of flexibility within a structured system.
           

          How can BD support?

          BD offers a large selection of IVDR compliant and RUO (GMP) single-colour reagents that give you the flexibility of setting up user-defined assays according to your needs. Select among many different fluorochromes, from dim to bright, depending on your panel.


          The BD FACSuiteApplication offers streamlined workflow features to support the development of user-defined assays. Unique and simple electronic assay portability enables sharing of user-defined protocols within and between institutions to simplify and standardise instrument setup within your lab and between labs, making collaboration effective and efficient. With one BD FACSuitesoftware menu for user-defined assays in the BD FACSuite Application and CE-IVD assays in the BD FACSuiteClinical Application, you can onboard your teams with less training effort.


          The BD FACSDuet Sample Preparation System integrated with the BD FACSLyricFlow Cytometer, with the addition of automated on-board washing and on-board centrifugation, further enhances lab’s efficiency, with the flexibility needed for workflows of user-defined assays . The onboard automated antibody cocktail preparation reduces hands-on-time and eliminates error prone steps due to manual pipetting.


          The BD Infinicyt Software provides flexibility in multiparametric CE-IVD data analysis when working with the intended uses of the appropriate BD CE-IVD panels, but also provides flexibility in the analysis of user-defined assays:

           

          • Manual analysis: As an aid in the diagnosis and monitoring of oncohaematological diseases and screening of suspected primary immunodeficiencies (CE-IVD analysis) and in the analysis of any user-defined assays.
          • BD Infinicyt™ profiles: Analysis templates in which the user can save the diagram configuration, reference images, analysis strategies and report configurations, among other options, to be used for specific analyses
          • File merge tool: Allows the user to combine different data files and merge their information into a single file

          Clinical Instruments

          Take your flow cytometric analysis to the next level with our cell analyzers offering workflow standardization and automation.

           

          Learn More

          Clinical Areas

          A comprehensive portfolio of clinical reagents and kits, and flow cytometers which can be used for diagnostic purposes in various clinical applications.

           

          Learn More

          Clinical Diagnostic Reagents

          Explore our expanding and comprehensive portfolio of high quality reagents and controls for a variety of clinical diagnostics applications.

           

          Learn More

           

          Informatics and Software

          From instrument-specific software to interfaces and powerful informatics, discover how we support you every step of the way in your flow cytometry analysis.

           

          Learn More

           

           

          BD Infinicyt™ Software

          Discover innovative tools for the analysis, integration and interpretation of multivariate flow cytometry data.

           

           

          Learn More

           

          Oncohaematology
          Down Arrow
          Immunology
          Down Arrow
          Transplantation and Transfusion
          Down Arrow
          Case Studies and Testimonials
          Down Arrow

          Start a Conversation with a BD Clinical Product Expert


          Find out how our complete line of clinical solutions can further your lab.

           

          *Required fields

          BD is committed to keeping your personal data protected and secure. More information on how we protect your personal data can be found in our privacy notice and our cookie policy.

          References

          1. World Health Organisation (WHO). Laboratory Quality Management System Handbook; 2011.
          2. Angeletti S, De Cesaris M, Hart JG, et al. Laboratory Automation and Intra-Laboratory Turnaround Time: Experience at the University Hospital Campus Bio-Medico of Rome. J Lab Autom. 2015;20(6):652-658.
          3. Howanitz J.H. and Howanitz P.J. Laboratory results. Timeliness as a quality attribute and strategy. Am J Clin Pathol. 2001;116(3):311-5
          4. Carraro P. and Plebani M. Errors in a Stat Laboratory: Types and Frequencies 10 Years Later. Clinical Chemistry. 2007;53: 1338-1342
          5. van Dongen JJM, Lhermitte L, Böttcher S, et al. on behalf of the EuroFlow Consortium (EU-FP6, LSHB-CT-2006-018708). EuroFlow antibody panels for standardised n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukaemia. 2012;26(9): 1908-1975. doi: 10.1038/leu.2012.120
          6. van Dongen JJM, van der Burg M, Kalina T,et al. EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid. System. Front. Immunol (2019) 10:1271. Front. Immunol 2019:10:1271. doi: 10.3389/fimmu.2019.01271.
          7. Van Der Burg M, Kalina T, Perez-Andres M et al. EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid. System. Front. Immunol (2019) 10:1271. doi:10.3389/fimmu.2019.00246.
          8. Langermayer I, Weaver C, Buckner CD, et al. Engraftment of patients with lymphoid malignancies transplanted with autologous bone marrow, peripheral blood stem cells or both. Bone Marrow Transplant. 1995;15(2):241-246.
          9. Sutherland DR, Nayyar R, Acton E, et al. Comparison of two single-platform ISHAGE-based CD34 enumeration protocols on BD FACSCalibur and FACSCanto flow cytometers. Cytotherapy. 2009;11(5):595-605.

          BD Flow Cytometers and BD FACSDuet™ Sample Preparation System and BD FACSDuet™ Premium Sample Preparation System are Class 1 Laser Products.

           

          BD FACSDuet™ Sample Preparation System, BD FACSDuet™ Premium Sample Preparation System, BD FACSLyric™ Flow Cytometer with the BD FACSuite™ Clinical and BD FACSuite™  Application,  BD Infinicyt ™ analysis software, SST Panel, BCP-ALL MRD Panel, MM MRD Panel, PIDOT Panel and Cytognos CE-IVD Single Colour Reagents (including CD38-multi-epitope-FITC), BD Multitest™ CD8/CD38/CD3/HLA-DR and BD Multitest™ CD8/CD38/CD3/HLA-DR with BD Trucount™ Tubes (333184 and 333185) are in vitro diagnostic medical devices bearing a CE mark.

           

           

           

          BD Multitest™ Reagents (excluding 333184, 333185), BD CE-IVD Single Colour Reagents, BD Leucocount™, BD OneFlow™ LST, BD OneFlow™ B-CLPD T1, BD OneFlow™ ALOT, BD OneFlow™ PCST, BD OneFlow™ PCD, BD® Stem Cell Enumeration Kit and  BD Trucount™ Tubes are in vitro diagnostic medical devices bearing a CE mark and are CE certified by BSI Group The Netherlands B.V. (Notified Body Number = 2797).

           

          The EuroFlow trademark is the property of the EuroFlow Consortium and cannot be reproduced or published without prior written permission from the EuroFlow coordinator (www.euroflow.org).